The Keithley 3722 offers two independent banks of 1×48 two-pole multiplexers, which is ideal for applications that require a high channel count. The two banks can automatically be connected to the Series 3700A mainframe backplane and optional DMM through the analog backplane connection relays. This connection allows the mainframe to reconfigure the card as a single 1×96 two-pole multiplexer or to enable card-to-card expansion for even larger configurations. Another feature of this card is the latching electromechanical relays. They can accommodate 300V, 1A switched signal levels.

The Keithley 3722 uses two 104-pin D-sub connectors for signal connections. A solder style connector kit (Model 3792-KIT104-R) and pre-assembled cables (Model 3722-MTC-1.5 and 3722-MTC-3) are available for card connections.